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Sunday, August 9, 2020 | History

2 edition of Phosphatidylcholine metabolism in the aorta. found in the catalog.

Phosphatidylcholine metabolism in the aorta.

Trevor Lukey

Phosphatidylcholine metabolism in the aorta.

by Trevor Lukey

  • 171 Want to read
  • 15 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (M.Sc.)- Univ. of Birmingham, Dept of Biochemistry.

ID Numbers
Open LibraryOL19886287M

Phosphatidylcholine predominates in most parts of the human body (tab. 1). The hydrophobic region of a phospholipid consists of the long hydrocarbon chains esterified to the 1- and 2-positions of the glycerol Size: KB. The pop sci article, and the headline & abstract of the report, focus on phosphatidylcholine (which is the form in lecithin and food), but the issue is that a small percentage of dietary or supplemental phosphatidylcholine (PC) can be degraded into free choline, which in turn is metabolized into trimethylamine (TMA) and trimethylamine N-oxide 5/5(3).

The emulsification of dietary fats renders them accessible to various pancreatic lipases in the small intestine. These lipases, pancreatic lipase and pancreatic phospholipase A 2 (PLA 2) generate free fatty acids and a mixture of mono- and diglycerides from dietary atic lipase degrades triglyceride at the sn-1 and sn-3 positions sequentially .   Mild hyperhomocysteinemia is a risk factor for many diseases, including cardiovascular disease. We determined the effects of insulin resistance and of type 2 diabetes on homocysteine (Hcy) metabolism using Zucker diabetic fatty rats (ZDF/Gmi fa/fa and ZDF/Gmi fa/?). Plasma total Hcy was reduced in ZDF fa/fa rats by 24% in the pre-diabetic insulin-resistant Cited by:

Lipid and energy metabolism was investigated in the aorta and brain microvessels to clarify the mechanisms of the formation of atherosclerosis or angionecrosis. The aorta had fairly high enzyme activities to hydrolyze or synthesize lipids in lysosomes and microsomes. Turmeric is commonly used for conditions involving pain and inflammation, such as osteoarthritis. It is also used for hay fever, depression, high cholesterol, a type of liver disease, and itching.


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Phosphatidylcholine metabolism in the aorta by Trevor Lukey Download PDF EPUB FB2

Chan AC, Leith MK. Decreased prostacyclin synthesis in vitamin E-deficient rabbit aorta. Am J Clin Nutr. Nov; 34 (11)– Arthur G, Choy PC. Acyl specificity of hamster heart CDP-choline 1,2-diacylglycerol phosphocholine transferase in phosphatidylcholine biosynthesis.

Biochim Biophys Acta. Sep 12; (2)–Cited by:   Lipid metabolism is significantly modified in the heart of vitamin A-deficient rats. In the left ventricle the content of total phospholipids increases due to an increase of phosphatidylcholine, phosphatidylethanolamine and phosphatidic acid, while cardiolipin, sphingomyelin, and lisophosphatidylcholine decrease compared to the control-fed by: Discovery of a relationship between gut-flora-dependent metabolism of dietary phosphatidylcholine and CVD pathogenesis provides opportunities for the development of new diagnostic tests and.

Phosphatidylcholine is approved for the treatment of atherosclerosis in many European countries. It is available there as Lipostabil, Essentiale or Plaquex. Our clinic orders intravenous Plaquex from Switzerland from the company that originally developed it.

It was originally developed to prevent post-surgical fatty emboli and is currently used. Day A.J. and Wahlqvist M.L.: The uptake and metabolism of 14 C-labeled oleic acid by atherosclerotic lesions in rabbit aorta. A biochemical and radioautographic study. Circ. Res. 23, () PubMed Google ScholarCited by: 1.

I’ve been writing a lot about choline lately. Most recently, my article entitled “Nonalcoholic Fatty Liver Disease: A Silent Epidemic of Nutritional Imbalance” contained a major section on the role of dietary choline in protecting against fatty liver disease, which itself is a powerful and independent risk factor for heart disease.

I also wrote a series dealing more specifically with. Abstract. Injections of polyunsaturated phosphatidylcholine solution in sodium desoxycholate are known to alter the activity of a number of enzymes of the aortic wall, that are involved in the metabolism of phospholipids, triglycerides and cholesteryl esters and Cited by: 1.

Phosphatidylcholine: It sure is a hard word to get your tongue around. Defined and Pro-nun-c-ia-tion by as: phosphatidylcholine phosphatidylcholine (fŏs’fə-tīd’l-kō’lēn’) n.

A phospholipid that is a major component of cellular membranesand functions in the transport of lipoproteins in tissues. Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure).

It is most commonly taken to be synonymous with the human forms of this enzyme, which play an important role in eukaryotic cell physiology, in particular signal transduction pathways. There are thirteen kinds of mammalian phospholipase. Question: Is there a danger in taking lecithin or phosphatidylcholine.

I heard that they may increase the risk of heart attacks. Answer: Although a direct link to heart attack has not been made, researchers recently showed that intake of phosphatidylcholine, a major component of lecithin, temporarily raises blood levels of the compound is of concern because a 3.

Take a look at the scientific evidence-based literature to support the statements we make in the book. Mastering Diabetes Book Scientific References.

The Revolutionary Method to Reverse Insulin Resistance Permanently in Type 1, Type. Atherosclerosis is a leading cause of morbidity and mortality in North America and results in major economic and health burdens across the globe [].Atherosclerosis is a chronic vascular disease initially involving the intima of elastic and larger muscular arteries and characterized by the presence of fibroinflammatory lipid plaques (atheromas).Cited by: 3.

This chapter discusses the composition and metabolism of arteries to an understanding of the degeneration of esterified fatty acids and cholesterol.

It is possible to distinguish the morphological changes that occur in arteries with age and with atherosclerosis from changes that occur in the chemical composition of the arterial by: The precise physiological role of PG, particularly prostacyclin (PGI2), in the control of CE metabolism in intact aortic smooth muscle cells remains to be fully elucidated.

The aorta (/ eɪ ˈ ɔːr t ə / ay-OR-tə) is the main and largest artery in the human body, originating from the left ventricle of the heart and extending down to the abdomen, where it splits into two smaller arteries (the common iliac arteries).The aorta distributes oxygenated blood to all parts of the body through the systemic ciation: /eɪˈɔːrtə/.

A new pathway has been discovered that links a common dietary lipid and intestinal microflora with an increased risk of heart disease. The study shows that people who eat a diet containing a. The aorta is a large artery that carries blood out of your heart.

If you have a dissection of the aorta, it means that blood is leaking outside of Author: Helen Colledge. Lysophosphatidylcholine acyltransferase 3 (Lpcat3) is involved in phosphatidylcholine remodeling in the small intestine and liver.

We investigated lipid metabolism in inducible intestine-specific Title: Postdoctoral Researcher at. Enteroviruses are among the most common causes of viral meningitis. Enteroviral meningitis continues to represent diagnostic challenges, as cerebrospinal fluid (CSF) cell numbers (a well validated diagnostic screening tool) may be normal in up to 15% of patients.

We aimed to identify potential CSF biomarkers for enteroviral meningitis, particularly for cases with normal CSF cell Cited by: 2.

Vitamin B 6 has also been shown to be important for fatty acid metabolism [12], with deficiency states linked to impaired cholesterol metabolism [13] and.

Metabolomics is an emerging technology that reveals homeostatic imbalances in biological systems. Global determination of metabolite concentrations in body fluid and tissues provides novel anatomical aspects of pathological conditions that cannot be obtained from target-specific measurements.

Here, we characterised metabolic imbalance in Watanabe heritable .Lipid metabolism is significantly modified in the heart of vitamin A-deficient rats. In the left ventricle the content of total phospholipids increases due to an increase of phosphatidylcholine, phosphatidylethanolamine and phosphatidic acid, while cardiolipin, sphingomyelin, and lisophosphatidylcholine decrease compared to the control-fed by: METABOLISM OF ARTERIAL TISSUE.

I adult rat provided sufficient material for a single determination. Since the thoracic aorta of the 1 to 2 month-old rat weighed less than 50 mg., it was necessary to pool the aortas of two or three such rats for a single de- termination.